List of House of Mouse villains from tv series and movies.
- Hades (main antagonist)
- Jafar, Scar, Randall, Captain Hook, Hopper, Ursula, Zira, Cruella De Vil, and Maleficent (secondary antagonist)
- Negaduck (first main antagonist)
- Merlock the Magician (second main antagonist)
- Megavolt, Bushroot, Liquidator, Quackerjack, Steelbeak,Tuskernini, Taurus Bulba, Hammerhead Hannigan, Hoof and Mouth, Ammonia Pine, Professor Moliarty, Lilliput Gooney, The Bug Master, Jambalaya Jake, Gumbo, Flintheart Glomgold, The Beagle Boys, Magica De Spell, Fat Cat and his gang, Rat Capone and his gang and Don Karnage and his pirates (secondary antagonist)